Multivariate analysis revealed presence of distant metastasis (OS; P = 0.005, RFS; P = 0.012) and Cy-FAM83H expression (OS; P <  0.001, RFS; P <  0.001) as independent indicators of poor prognostic of OS and RFS in osteosarcoma patients. This evidence concerns the gene SACK1H and osteosarcoma.