IGF1 and plasma cell myeloma: High levels of IGF-1R, and/or its activating ligands IGF-1 and IGF-2 have been associated with various types of human cancer (e.g. multiple myeloma, breast, prostate, colon, lung, pancreas, Ewing’s sarcoma) and also found to correlate with increased invasiveness and metastatic potential [14–16].