CASP9 and neoplasm: In addition, some research also reported that beta elemene can reduce the expression of Bcl-2 in lung cancer and prostate cancer, increase the expression of cytochrome C, ADP ribose polymerase (PARP), caspase 3, caspase7 and caspase 9 [33] with a dose dependent manner in in vivo anticancer effect, and the half antitumor inhibitory concentration values (50% Inhibiting concentration, IC50) are up to hundreds of micromole in different types of tumor cells [34–36].