TP53 and familial pancreatic carcinoma: Furthermore, there also displayed the increase protein expression of P53 and the decrease Bcl-2 protein expression in the low dosage group (20 mg/kg, P < 0.05), but not as good as the high dose group, which suggesting that the regulation of pancreatic cancer on the protein levels of P53 and Bcl-2 with a dose dependent relationship.