In addition to controlling metabolism reprogramming in cancer, FBXW7 is implicated in the maintenance of glucose and lipid homeostasis during metabolic syndrome, such as mediating lipid metabolism by triggering SREBP1 degradation, facilitating glucose homeostasis through promoting fetuin A degradation and perturbing systemic lipid and glucose metabolism via targeting REV-ERBα for degradation, which may contribute to the development of NAFLD (Onoyama et al. 2011; Tu et al. 2012; Zhao et al. 2016, 2018). The gene discussed is SREBF1; the disease is cancer.