ESR1 and endometrial cancer: DACH1 is a well‐conserved nuclear protein related to the Sno/Ski family of co‐repressors.11 Mounting evidence from recent studies show that DACH1 expression altered in many hormone‐responsive cancer (ovary, breast, prostate)12, 13, 14 and DACH1 could regulate hormone receptor signaling.12, 14 In breast cancer, associating with estrogen receptor (ER), DACH1 could inhibit estradiol‐induced DNA synthesis and cellular proliferation.12 We previously found that the DACH1 expression decreased in endometrial cancer.15 It indicated that DACH1 might be a tumor suppressor in EC.