It has been verified that DACH1 could colocalized with ERα in breast cancer and AR in normal prostate.12,14 Whether DACH1 could directly bind with PR and its underlying mechanism remains elusive Understanding the molecular mechanism between DACH1 and PR involved in progestin resistance will be used to design better intervention strategies to predict and reverse progestin resistance of EC. The gene discussed is PGR; the disease is breast cancer.