Numerous evidence have shown the vital role of EMT in chemoresistance of diverse cancer (breast cancer, bladder cancer, and pancreatic cancer).18, 19, 20, 21 Our results showed that epithelial markers E‐cadherin and β‐catenin were dramatically decreased, and mesenchymal markers Vimentin and N‐cadherin were increased in IshikawaPR cell. Here, CDH2 is linked to familial pancreatic carcinoma.