DACH1 is a highly conserved nuclear protein localizes to chromosome 13q21.23 Recent studies have demonstrated that DACH1 expression is altered in different types of hormone‐responsive cancers (breast, ovary, and prostate).12, 13, 14 The inhibition role of DACH1 in oncogene‐induced cellular proliferation and migration is verified in breast cancer cells and DACH1 regulates hormone‐dependent signaling.12, 14 Hence, we explored the functional studies of DACH1 in EC cell. The gene discussed is DACH1; the disease is breast cancer.