HIF1A and liver dysplastic nodule: The HIF-1A Pro582Ser polymorphism seems to be a common protective risk for DR and DN since inclusion of microalbuminuria (that strongly correlates with severe DR with OR 14.77, p < 0.0001) in the multiple logistic regression model drops the significance of the protective effect of the HIF-1A Pro582Ser polymorphism for severe DR (p = 0.051) (data not presented).