In conclusion, our case-control study identified nine SNPs of SIRT1/ SIRT2 gene with PD in Chinese Han population for the first time and observed that two SNPs, rs12778366 and rs2015, were associated with the risk of PD in the Chinese Han population, and the rs2015 polymorphism may influence SIRT2 expression by affecting the binding of miR-8061 to the 3′UTR of SIRT2, ultimately contributing to the risk of PD. This evidence concerns the gene SIRT2 and Parkinson disease.