Since hypoxia and HIF-1α are known to be involved in promoting the self-renewal capacity of CD133 (22) -and CD90 positive cells, to understand the effect of MET on glioma markers of malignancy, U251 and T98 cells were analyzed in hypoxic condition for the expression of these markers together with CD73 and CD44. This evidence concerns the gene PROM1 and central nervous system cancer.