PPP2R1A and neoplasm: In accordance, ectopic expression of several Aα mutants, among which p.P179R and p.S256F, in the wild-type PPP2R1A-expressing HEC-1A EC cell line, resulted in increased anchorage-independent cell growth and increased xenografted tumor growth in nude mice, and correlated with increased Akt and mTOR/S6K oncogenic signaling (102).