CD19 and acute lymphoblastic leukemia: The first was approved was in August 2017 for the treatment of patients aged up to 25 years carrying B-cell precursor acute lymphoblastic leukemia (ALL) to CD19 cell therapy CART-4-1BB (tsagenlecleucel CTL019, Kymriah, Novartis, Basel, Switzerland) (20, 83, 84).