In Shanghai CRC screening program, FIT, the most widely used qualitative CRC screening method, was used to identify high-risk individuals using a cutoff value of fecal hemoglobin (Hb) ≥100 ng/ml (20 μg Hb/g feces) based on evidence from Chinese (18) and other populations (4, 19, 20). This evidence concerns the gene GSTM1 and colorectal carcinoma.