Then, they employed qRT-PCR to detect the expression levels of FOXN3 in the bone marrow of 97 cases of acute leukemia [78 AML cases, and 19 acute lymphocytic leukemia (ALL) 19 cases] and 16 normal humans, and found that the expression levels of FOXN3 in patients with ALL and AML were decreased to varying degrees, especially in AML patients in whom the expression level of FOXN3 was significantly different from that in the normal controls. This evidence concerns the gene FOXN3 and acute leukemia.