In a study on the changes in the expression levels of genes of T-cell large granular lymphocyte leukemia (T-LGL), they used such research methods as multicolor fluorescence in situ hybridization, gene sequencing and LM-PCR and found that there was an increase in FOXN3 gene expression in a T-LGL patient with gene amplification in 14q, indicating that sub-genomic rearrangement alters the gene expression in patients with T-LGL, and that it is associated with the pathogenesis and survival pattern of T-LGL (76). The gene discussed is FOXN3; the disease is T-cell large granular lymphocyte leukemia.