To further explore the effect of FOXN3 in the progression of colon cancer, they overexpressed and knocked down the FOXN3 gene in colon cancer cell line, and then used such experimental methods as MTT, soft agar assay, cell migration assay, cell invasion, and flow analysis, whereby they confirmed that FOXN3 could inhibit the proliferation, migration, and invasion of colon cancer cells and inhibit cell cycle progression. Here, FOXN3 is linked to malignant colon neoplasm.