As a result of the high expression of ADAM12 and the low expression of CHES1 in laryngeal carcinoma, they analyzed the presumed diagnostic values of the ratios of expressions of CHES1 and ADAM12 genes by setting the threshold of the ratio of the two genes (ADAM12/CHES1) at 0.4. Here, FOXN3 is linked to laryngeal carcinoma.