FOXN3 protein can inhibit the expression of the PIM2 gene and protein biosynthesis, thereby regulating cell proliferation (73); similarly, studies on three different types of lymphomas revealed that the expression of CHES1 in primary exudative lymphoma, diffuse large B-cell lymphoma and hairy cell leukemia was reduced. The gene discussed is FOXN3; the disease is diffuse large B-cell lymphoma.