In a recent publication, Zhuanget al. 34 provide evidence for reduced bacterial burden of theΔlmp1 mutant in mouse tissues at 3 weeks post-infection, the requirement for both the N-terminal and middle domains in tick-to-mouse transmission, the existence of multiple Lmp1 species, and the degradation of Lmp1 by the periplasmic serine protease BbHtrA34. The gene discussed is PDLIM7; the disease is infection.