Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) delivers lipid-derived energy to liver cells, and suppression of HMGCS2 in the nonalcoholic steatohepatitis livers could indicate impairment of ketogenesis and cholesterol biosynthesis [47]. The gene discussed is HMGCS2; the disease is metabolic dysfunction-associated steatohepatitis.