PRRT2 and diabetes mellitus: The development of not only β-cell dysfunction and insulin resistance but also the late complications of diabetes has been linked to hyperglycaemia-induced oxidative stress through the four main molecular mechanisms: the polyol pathway, advanced glycation end product (AGE) formation, the protein kinase C- (PKC-) diacylglycerol (DAG), and the hexosamine pathways [26, 27].