Given that, we reanalyzed the WES datasets including 10 familial non-BRCA1/BRCA2 BC pedigrees (Gracia-Aznarez et al., 2013; Hilbers et al., 2013), manually evaluated variants as recommended (Hampel et al., 2015), and performed data mining on pan-cancer datasets. This evidence concerns the gene BRCA1 and breast cancer.