IGF2R and cancer: In our analysis, we found that seven out of 10 pedigrees had potential co-segregated pathogenic variants in known cancer-associated genes (Table 1 and Supplementary Table S1), including CHEK2, ATM, MRE11, and CTR9, and some other cancer-associated genes, such as IGF2R and CHRNA3 (Table 1 and Supplementary Table S1).