Moreover, treatment with curcumin exhibited reactivation of silenced tumor suppressive genes by inducing demethylation of promoters of these genes (e.g., RARβ2 in human cervical cancer cell lines and p15INK4B in acute myeloid leukemia), leading to a remarkable tumor suppression (Jha et al., 2010; Yu et al., 2013). The gene discussed is CDKN2B; the disease is neoplasm.