Our previous studies have shown that effects of gene-gene and gene-environment interactions on IgE production begin in the prenatal stage, female children with null genotype of GSTM1 are more susceptible to tobacco-associated asthma, and male children of non-atopic parents living without air filters had a higher risk to asthma (Liu et al., 2003; Yang et al., 2010; Wu et al., 2014; Lee et al., 2017). Here, IGHE is linked to asthma.