N-[4-(difluoromethoxy)phenyl]-2-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]-acetamide (Figure 2B) bound selectively to the MMP-9 HPX domain with KD = 2.1 μM and inhibited tumor growth and lung metastasis in MDA-MB-435 mouse models (80). This evidence concerns the gene MMP9 and neoplasm.