To investigate the specific role of CD8+ T cells in immune surveillance in the ID8-fLuc ovarian cancer model, we performed a depletion experiment by which we inoculated C57BL/6 mice with ID8-fLuc and started treating the mice with anti-CD8 20 days after tumor inoculation (onset of exponential tumor growth phase, as demonstrated earlier) (20) In this experiment, we did not observe a difference in tumor burden 6 weeks after inoculation between anti-CD8 treated and control mice, which corresponds to the results obtained with B6.129S7-Rag1tm1Mom/J mice (Figures 1C,D). This evidence concerns the gene CD8A and neoplasm.