APC and nasopharyngeal carcinoma: These apparent discrepancies between mouse and human CD1d lipid antigen presentation in NPC and Fabry diseases could be related to: (i) the described differences in intracellular trafficking between human and mouse CD1d; (ii) the discrepancy in lysosomal function between LSD patients and mouse models; (iii) the different type of APC used in mouse and human studies.