In a recent study, mice treated with anti-epiplakin antibodies showed loss of cell–cell adhesion in the respiratory epithelium (32), suggesting that anti-epiplakin antibody may play a pathogenic role in bronchiolitis obliterans, although epiplakin is located within the subcellular area of epithelial cells (62). The gene discussed is EPPK1; the disease is bronchiolitis obliterans syndrome.