EGFR and colorectal cancer: Another detrimental effect of anti-α-Gal immunity is the α-Gal syndrome (AGS), which is caused by IgE Abs directed against α-Gal and which is characterized by two different forms of anaphylactic reactions: delayed allergic reactions after ingestion of red meat and immediate reactions in response to tick bites and during intravenous exposure to cetuximab, a chimeric mouse-human IgG1 monoclonal Ab (mAb) specific for the epidermal growth factor receptor (EGFR) used in the treatment of colorectal cancer (14–17).