TGFB1 and neoplasm: Among them, lenalidomide seems to be the most active drug which overcomes suppression of human NK cell anti-tumor functions by TME-associated IL-6 and TGF-β and lowers the threshold of MICA for NKG2D-mediated NK cell activation and augments nanoscale rearrangements in cortical actin at the NK cell ADCC immune synapse (111, 112).