In addition, the cytotoxicity of NK cell was found to be inhibited by activated-platelets in the malignant milieu via a series of mechanisms, including the shed and transfer of their MHC class I molecules to tumor cells; undermining NK cell effector function via platelet-derived TGF-β (14) or shielding tumor cells from NK cell attack (15–17). The gene discussed is TGFB1; the disease is neoplasm.