INS and type 2 diabetes mellitus: In a study conducted on the German population involved in the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) S4/F4 study, lower values of adiponectin have been demonstrated to be associated with higher risk of T2D in insulin resistant individuals, estimated by homeostasis model assessment (HOMA-IR), but not in insulin sensible ones; this evidence suggests that low adiponectin may have a deleterious effect only in presence of IR.