VDAC1 and neurodegenerative disease: While the exact composition of the mPTP, which initially included the voltage dependent anion channel (VDAC), is still a matter of debate, its opening constitutes a common feature of many pathological conditions (Halestrap and Brenner, 2003) including neurodegenerative diseases (Du and Yan, 2010; Quintanilla et al., 2017).