Proteoglycans have been found to be critical in the regulation of stem cell through inducing precise and coordinated modulation of key growth factors, resulting in selective mitogen-activated protein kinases (MAPK) and/or another intracellular signaling, demonstrating an aberrant expression of ligand-receptor interaction on immune cells in IBD patients (Elshal et al., 2016; Gawronska et al., 2017). Here, WNK2 is linked to inflammatory bowel disease.