For example, TAG accumulation has been observed in both mice and rats treated with STZ or alloxan (Denton and Randle, 1967; Finck et al., 2003; O’Donnell et al., 2006; Han et al., 2007), Akita mice (Basu et al., 2009), mice overexpressing peroxisome proliferator-activated receptor-alpha (PPARα) and treated with STZ (a severe T1DM phenotype) (Finck et al., 2003), mice fed a diabetogenic high-fat, high-sugar diet (Abdesselam et al., 2015) and the Zucker fatty rat (Coort et al., 2004). This evidence concerns the gene PPARA and type 1 diabetes mellitus.