CNR1 and breast cancer: For instance, AEA exerts a potent CB1R-mediated effect on the proliferation of MCF-7, and EFM-10 human breast cancer cells (Di Marzo et al., 1998), while in N18TG2 murine neuroblastoma cells, the effect is due to FAAH-mediated degradation of AEA to ethanolamine (Matas et al., 2007).