In cancer murine 4T1 and human MCF-7 mammary carcinoma cells, the action of JWH-015 seems to be complex, since it is not mediated either by CB1R or CB2R, or by GPR55, TRPV1, or TRPA1 receptors (Hanlon et al., 2016). The gene discussed is TRPV1; the disease is cancer.