Up-regulated MHC I/II, microphthalmia-associated transcription factor (MITF), Wnt, myosin and IL-1R, down-regulatedβ-tubulin (TUBB), Rab31 and triggered TCR signaling, activating immune cytokine IL-2, transforming growth factor-β (TGFβ), IL-2 and Fas-ligand [FasL, thus further activating immunoreaction of natural killer cell (NK cells), macrophage, mast cells as well as remove infected or cancer cells]. The gene discussed is IL1R1; the disease is cancer.