For example, suppression of macrophage-derived IL-12 production may prevent the differentiation of self-reactive T helper type-1 (Th1) CD4+ cells and autoimmunity (Trembleau et al., 1995), while AC-induced IL-10 represses the expression of MHC-II and costimulatory molecules required for antigen presentation and subsequent T cell activation (Couper et al., 2008). This evidence concerns the gene IL10 and Autoimmunity.