For these tumor types, five cancer drivers were targeted only by NPs at < 100 nM, including Adenylate Cyclase 1 (ADCY1), Matrix Metallopeptidase 2 (MMP2), Aryl Hydrocarbon Receptor (AHR), Cyclin Dependent Kinase 2 (CDK2), and Mitogen-Activated Protein Kinase 11 (MAP3K11). The gene discussed is MAP3K11; the disease is cancer.