DAG and IP3 signaling was not enriched with cancer drivers and did not have any low affinity CT drug targets, but did have six high affinity NP targets: PRKCG, E,A,D (Protein Kinase C), PDE1A (Phosphodiesterase 1A) and ADCY1 (Adenylate Cyclase 1). This evidence concerns the gene PRKCG and cancer.