In addition, berberine, a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids, was shown to attenuate adverse left ventricular remodeling and improve cardiac function in acute myocardial infarction animal models through autophagy induction mediated by the activation of p38 MAPK inhibition and phosphor-Akt activation (Zhang et al., 2014). Here, AKT1 is linked to myocardial infarction.