Furthermore, human cellular repressor of E1A-stimulated genes (CREG), a secreted glycoprotein that regulated tissue and cell homeostasis, was reported to attenuate cardiac fibrosis after ischemia/reperfusion injury through the inhibition of apoptosis and enhancement of autophagy via regulation of lysosomal protein transfer, indicating a potential protective effect of CREG in myocardial infarction (Song et al., 2017). This evidence concerns the gene CREG1 and myocardial infarction.