(2017) demonstrated that knockdown of microRNA-122 protected cardiomyocytes against hypoxia injury via the induction of chromosome 10 (PTEN)-PI3K-Akt signaling-mediated autophagy, indicating that targeting microRNA-122 might be a potential therapeutic strategy in the treatment of acute myocardial infarction. The gene discussed is AKT1; the disease is myocardial infarction.