SIRT7 and acute myocardial infarction: In addition, transforming growth factor-β receptor I downregulation induced by loss of Sirt7, a kind of factor in response to acute myocardial infarction, was blocked by autophagy inhibitor, indicating that Sirt7 could maintain transforming growth factor receptor I via modulating autophagy in tissue repair process in response to ischemic injury (Araki et al., 2015).