Polymorphism p53 is often found in high level preinvasive lesions (severe dysplasia, H-SIL) and invasive cervical cancer In variations of type dysplasia of a mild degree L-SIL, the DNA remains in a circular form and does not integrate in in the host genome as opposed to the change of type H-SIL, where the DNA is integrated into the host genome at sensitive chromosome points. The gene discussed is TP53; the disease is cervical cancer.