Data from the Ginkgo Evaluation of Memory study showed evidence that extraversion and neuroticism could potentially modify the association of the APOE ε4 allele with cognitive decline and Alzheimer’s disease, such that the associations of high neuroticism with faster cognitive decline and an increased risk of Alzheimer’s disease were evident only among the ε4 allele carriers and that higher extraversion magnified the deleterious effect of the APOE ε4 allele on cognitive function and the risk of Alzheimer’s disease (Dar-Nimrod et al., 2012). This evidence concerns the gene APOE and Mental deterioration.