Two classical pathological features of AD are aberrant phosphorylated forms of tau protein and pathologically generated Aβ peptides (Lee et al., 2001; Alavi Naini and Soussi-Yanicostas, 2015; Bejanin et al., 2017; Bourdenx et al., 2017; Sun et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.