RHO and amyotrophic lateral sclerosis: Rho signaling is involved in several cerebral diseases, including intellectual disability (ID), epilepsy, drug addiction, HD, amyotrophic lateral sclerosis (ALS), and AD, and it acts by regulating axonogenesis, neuronal migration and synaptic plasticity (Table 3) (Mendoza-Naranjo et al., 2007; Locke et al., 2009; Zhang Y. et al., 2015; Li et al., 2016; Wang et al., 2017; Zimering, 2018; Costain et al., 2019).