In vitro experiments also demonstrated that treatments of rat primary neurons, astrocytes, and human neuroblastoma cells with 1–10 μM 27-OHC stimulate the production of angiotensinogen, the precursor of Ang I. Moreover, in AD the activity of ACE correlates with 27-OHC levels both in plasma and CSF (Mateos et al., 2011a), although ACE levels have been shown to be reduced in the CSF (Miners et al., 2009). The gene discussed is ACE; the disease is Alzheimer disease.