Previous studies have linked hnRNP E2 to caspase-3 activation; hnRNP E2 is upregulated in human glioma tissue, while hnRNP E2 knockdown inhibited glioma growth through the induction of caspase-3-mediated apoptosis and the inhibition of cell-cycle progression (Han et al., 2013). Here, CASP3 is linked to central nervous system cancer.