In addition, the recent implication of hnRNP A2/B1 and hnRNP A1 in ALS and multisystem proteinopathy supports the hypothesis of a physical and functional interaction between TDP-43 and other hnRNPs (Calini et al., 2013; Kim et al., 2013; Romano et al., 2014). The gene discussed is TARDBP; the disease is proteostasis deficiencies.