TNF and neoplasm: Indeed, quantitative analysis of the rise in human (i.e., CAR T cell derived) IL-2, IL-10, IFN-γ, and TNF-α concentrations upon elevation of injected CAR T cells revealed that the above cytokines can increase by an average of 30- to 8000-fold when tumor-bearing mice that have been infused with 12.5 million CAR T cells are subsequently treated with FITC-folate adapter.