In order to identify hub genes in the process of RCC carcinogenesis, closeness centrality of DEmRNAs was calculated using cytoHubba plugin, and the top 8 hub genes were found to be BUB1, RAD51, GINS2, CDC6, MELK, OIP5, PLK1, and TRIP13 (Figure 5B). This evidence concerns the gene CDC6 and renal cell carcinoma.