In order to identify hub genes in the process of RCC carcinogenesis, closeness centrality of DEmRNAs was calculated using cytoHubba plugin, and the top 8 hub genes were found to be BUB1, RAD51, GINS2, CDC6, MELK, OIP5, PLK1, and TRIP13 (Figure 5B). The gene discussed is BUB1; the disease is renal cell carcinoma.