F2RL1 and esophageal cancer: Oncogenic function of PAR-2 has been reported in ovarian clear cell carcinoma [13], esophageal cancer [15], pancreatic cancer [16], hepatocellular carcinoma [17], etc. Sun et al. found that PAR-2 might promote the migration and invasion of renal cell cancer cells through activating the PI3K/AKT signaling pathway [18].