Anti-influenza activity of the human and bovine chimeric Mx proteins was studied by substituting the GTPase effector domain (GED) of the human Mx protein with bovine and vice versa, and demonstrated that bovine Mx1 proteins exhibited an increased activity against the influenza virus particularly the motifs located in its N-terminal portion is responsible for the interaction with the cellular and viral factors [225]. The gene discussed is MX1; the disease is influenza.