The most promising LSD1 inhibitors in AML appear to be (i) the tranylcypromine-based compounds such as tranylcypromine (TCP) trentinoin (in combination with all-trans retinoic acid, ATRA) against relapsed/refractory AMLs, (ii) GSK2879552 (GlaxoSmithKline), evaluated in small cell lung cancer and AML, and (iii) ORY-1001 (iadademstat, Oryzon Genomics), which entered phase I clinical trials in AML [187,188]. The gene discussed is KDM1A; the disease is acute myeloid leukemia.