MI-1481 reduced HOXA9 and MEIS1 expression and increased CD11b gene expression in a MV4-11 human AML cell model in culture, as well as in vivo, as shown in MV4-11 cells isolated from bone marrow and the spleen after six days’ treatment with MI-1481 of MV4-11 engrafted mice [148]. Here, MEIS1 is linked to acute myeloid leukemia.