Interestingly, deguelin has multiple mechanisms of action in AML and also increases NUP98 binding to the nuclear pore in the U937 cell line [222]; possible re-localization of NUP98-HOXA9 from DNA to the nuclear pore under deguelin treatment, and the subsequent consequences in terms of cell survival and differentiation, would be a mechanism that would be interesting to evaluate. Here, NUP98 is linked to acute myeloid leukemia.