Similar to fibrogenesis, both the formation of angiogenesis and cirrhosis are mediated by extracellular matrix remodeling and the activation of growth factors, including but not exclusive of TGF-β, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), and increased gene expression of adhesion molecules [55,56]. This evidence concerns the gene VEGFA and Cirrhosis.