MMP14 and metastatic melanoma: Microarray gene chip analysis has revealed increased expressions of laminin 5, membrane type 1-matrix metalloproteinases (MT1-MMP), and MMP-1, -2, -9, and -14 in aggressive metastatic melanoma cells compared to poorly aggressive ones, and the inhibition of the interaction between laminin-5 and MMP-2 and MT1-MMP with specific antibodies inhibits the formation of the tubular network, suggesting a strong implication of these components in vasculogenic mimicry [122].