NODAL and hepatocellular carcinoma: Additionally, a significant overexpression of EMT transcription factors involved in both the acquisition of stem cell-like properties and vasculogenic mimicry have been observed in different tumours, such as Nodal in murine melanoma and human cutaneous melanoma [102,103,104,105], Twist in hepatocellular carcinoma [106,107,108], Bcl-2 in human melanoma and hepatocellular carcinoma [108,109], Zinc-finger E-box binding homeobox (ZEB) in hepatocellular, pancreatic, and colorectal carcinoma, [110,111,112], or Snail in human breast and oral squamous cell carcinomas [113,114], amongst others.