In 2014, a study administering 400 IU of vitamin E twice daily to a group of patients with genotype 3 CHC similarly showed a reduction in serum ALT after 12 weeks, from 122.6 ± 80.1 IU/L to 68.4 ± 25.3 IU/L, p = 0.016 [168]. This evidence concerns the gene GPT and cryohydrocytosis.