CXCL8 and Graves ophthalmopathy: Previous ophthalmic studies suggested that quercetin reduced IL-6 and IL-8 mRNA expression in cultured tissue from Graves’ orbitopathy [16], attenuated IL-6, IL-8 and ICAM-1 mRNA levels in IL-1β-stimulated orbital fibroblasts from Graves’ orbitopathy [86], and inhibited IL-6 and IL-8 secretion in TNF-α-stimulated human corneal epithelial (HCE) and conjunctival (IOBA-NHC) cell lines [87].