In MDA-MB-231 breast cancer cells that harbor genetic inactivation of the Hippo pathway (NF2 null), approximately 80% of TEAD4-bound promoters and enhancer regions were co-occupied with YAP/TAZ, while the TEAD consensus sequence was present in 75% of DNA-bound YAP/TAZ peaks [32]. This evidence concerns the gene WWTR1 and breast cancer.