Although oncogenic driver mutations in TEAD are yet to be identified, the TEAD transcriptional output was found to be responsible for human malignancies via the crosstalk between various oncogenic signaling pathways and cancer genes such as the Hippo pathway, EGFR-RAS-RAF-MEK pathway, LKB1, GNAQ/11, and MYC (Figure 2a). The gene discussed is STK11; the disease is cancer.