It is also accepted that epigenetic mechanisms could be related to the maintenance of inflammation, contributing to the progression of diabetes and its vascular complications [67]: the inflammatory phenotype of cells involved in immune responses, including endothelial cells (ECs), triggers the activation of the NF-kB nuclear complex that induces the transcription of a number of genes related to the inflammatory response, such as those coding for both cytokines (IL1, IL6 and TNFα) and adhesion molecules (VCAM1, ICAM1 and MCP-1). Here, TNF is linked to diabetes mellitus.