SETD7 and renal fibrosis: Histone H2AK119 mono-ubiquitination (H2AK119-Ub) has a key role in regulating Set7 activity; accordingly, lower levels of Set7 and prevention of renal fibrosis have been correlated to increased protein expression of H2AK119-Ub in response to aspirin in glomeruli from diabetic animals [151].