SIRT1 and diabetes mellitus: In the context of diabetes, the aberrant overexpression of miR-200c causes down-modulation of SIRT1, inhibits the transcription of FOXO1, increases the phosphorylation of p66Shc protein on Ser-36 and inhibits ROS scavenger expression/activity, thus contributing to enhance the oxidative stress as well as the formation of atherosclerotic plaque [110].