LAPTM5 (lysosomal-associated protein transmembrane 5) is one of the top genes significantly associated with longer survival in metastatic melanoma [61], and ITGB2 (integrin beta 2) co-expression with HLA-DR participates in signal transduction, cell adhesion, and motility in neoplastic melanocytes [5,62]. This evidence concerns the gene ITGB2 and metastatic melanoma.