Specifically, as compared with in vitro cell lines of cutaneous melanoma, HLA class II gene expressions in resected tissues of melanoma tumors were generally higher, particularly HLA-DMA, -DMB, -DPA1, -DPB1, -DQA1, -DQB1, -DRA and -DRB1, as displayed in Figure 5. This evidence concerns the gene HLA-DQA1 and cutaneous melanoma.